Player Draft
| Name | State | School | Class | Pos. | Year | Round | Team |
| Michael Sirota | CT | The Gunnery | 2021 | OF | 2024 | 3 | Reds |
| Brandyn Sittinger | OH | Keystone | 2012 | RHP | 2016 | 17 | Tigers |
| Kyle Skeels | PA | Neshaminy | 2015 | C | 2019 | 36 | Cardinals |
| Ethan Skender | IL | Metamora | 2015 | SS | 2016 | 28 | Padres |
| Paul Skenes | CA | El Toro | 2020 | RHP | 2023 | 1 | PIT |
| Carson Skipper | AL | Hewitt Trussville | 2018 | LHP | 2022 | 11 | Rockies |
| Evan Skoug | IL | Libertyville | 2014 | C | 2017 | 7 | White Sox |
| Johnny Slater | MI | Southfield-Lathrup | 2013 | OF | 2017 | 28 | Mariners |
| Jake Slaughter | LA | Ouachita Christian | 2016 | SS | 2018 | 18th | Cubs |
| Ryan Sloan | IL | York | 2024 | RHP | 2024 | 2 | Mariners |
| Ethan Sloan | CO | Cherokee Trail | 2020 | OF | 2024 | 8 | Tigers |
| Ryan Sloniger | PA | Punxsutawney Area | 2015 | C | 2019 | 38 | Blue Jays |
| Jackson Smeltz | IN | McCutcheon | 2018 | LHP | 2022 | 10 | Padres |
| Matthew Smith | PA | Seneca Valley | 2012 | RHP | 2016 | 34 | Brewers |
| Angelo Smith | IL | Richards | 2017 | LHP | 2017 | 40 | White Sox |
| Kevin Smith | NY | Columbia | 2014 | - | 2017 | 4 | Blue Jays |
| Austin Smith | FL | Park Vista | 2015 | RHP | 2015 | 2 | Padres |
| Josh Smith | LA | Catholic (BR) | 2016 | SS | 2019 | 2nd | Yankees |
| Marcus Smith | MO | Pembroke Hill | 2019 | OF | 2019 | 3 | A's |
| Jake Smith | NC | Chapel Hill | 2018 | RHP | 2018 | 21 | Philadelphia Phillies |
| Kyle Smith | NC | New Hanover | 2019 | C | 2019 | 36 | Arizona Diamondbacks |
| LaRon Smith | AB | Okotoks Dawgs Academy | 2018 | SS | 2018 | 25 | Minnesota Twins |
| Cade Smith | MS | DeSoto Central | 2020 | RHP | 2023 | 6 | Yankees |
| D'Andre Smith | CA | San Dimas | 2020 | SS | 2022 | 5 | Mets |
| Hagen Smith | TX | Bullard | 2021 | LHP | 2024 | 1 | White Sox |
| Kelvin Smith | GA | Redan | 2018 | SS | 2018 | 20th | Tigers |
| Cameron Smith | FL | Palm Beach Central | 2022 | 3B | 2024 | 1 | Cubs |
| David Smith | PA | Perkiomen School | 2019 | 2B | 2023 | 14 | Tigers |
| Tristan Smith | SC | Boiling Springs | 2022 | LHP | 2024 | 5 | Reds |
| Sincere Smith | NC | East Bladen | 2018 | SS | 2018 | 32 | New York Yankees |
| Myles Smith | CA | Crossroads | 2021 | SS | 2024 | 7 | Reds |
| Brady Smith | TN | Grainger | 2023 | RHP | 2023 | 3 | Dodgers |
| Ryan Smith | IL | Nazareth Academy | 2021 | SS | 2024 | 9 | Astros |
| Aidan Smith | TX | Lovejoy | 2023 | OF | 2023 | 4 | Mariners |
| Parker Smith | TX | Bellaire | 2021 | RHP | 2024 | 4 | Astros |
| Cade Smitherman | TX | Lovejoy | 2019 | OF | 2017 | 16 | Twins |
| Matt Smoral | OH | Solon | 2012 | LHP | 2012 | 1 | Blue Jays |
| Ryan Snell | TX | Hardin | 2018 | RHP | 2023 | 7 | Nationals |
| Robby Snelling | NV | McQueen | 2022 | LHP | 2022 | CBA | Padres |
| Hayden Snelsire | MD | Stephen Decatur | 2019 | RHP | 2023 | 17 | Rays |
| DJ Snelton | IL | Lakes | 2010 | LHP | 2013 | 9 | Giants |
| Michael Snyder | CA | Harvard Westlake | 2019 | 3B | 2024 | 10 | Marlins |
| Trey Snyder | MO | Liberty North | 2024 | SS | 2024 | 5 | Mets |
| Tyler Soderstrom | CA | Turlock | 2020 | C | 2020 | 1 | Oakland |
| Nick Solak | IL | Naperville North | 2013 | SS | 2016 | 2 | Yankees |
| Noah Soles | NC | Ledford | 2019 | OF | 2019 | 19 | Arizona Diamondbacks |
| Anthony Solometo | NJ | Bishop Eustace | 2021 | LHP | 2021 | 2 Pick 37 | Pittsburgh Pirates |
| Jared Solomon | PA | Millville | 2015 | RHP | 2017 | 11 | Reds |
| Tommy Sommer | IN | Carmel | 2017 | LHP | 2021 | 10 | White Sox |
| Jake Sommers | WI | Hortonville | 2015 | RHP | 2019 | 10 | Cardinals |
| Drew Sommers | CA | Carlsbad | 2019 | LHP | 2022 | 11 | Rays |
| Logan Soole | CO | Monarch | 2015 | LHP | 2015 | 23 | Diamondbacks |
| Zack Soria | IL | St. Rita | 2012 | C | 2017 | 18 | Braves |
| Gustavo Sosa | NY | Tottenville | 2019 | C | 2022 | 10 | Phillies |
| Charlee Soto | FL | Reborn Christian Academy | 2023 | RHP | 2023 | 1-A | Twins |
| Jared Southard | TX | Rouse | 2019 | RHP | 2022 | 12 | Angels |
| Ty Southisene | NV | Basic | 2024 | SS | 2024 | 4 | Cubs |
| Logan Sowers | IN | McCutcheon | 2014 | OF | 2018 | 28 | White Sox |
| Garrett Spain | TN | Clarksville | 2018 | OF | 2021 | 15 | Blue Jays |
| Chad Spanberger | IL | Granite City | 2014 | C | 2017 | 6 | Rockies |
| Zach Spears | IN | Mt. Vernon | 2015 | LHP | 2018 | 8 | Pirates |
| Tommy Specht | IA | Wahlert Catholic | 2022 | OF | 2022 | 6 | Rangers |
| Joey Spence | WI | West Bend East | 2021 | C | 2021 | 18 | Arizona Diamondbacks |
| John Spikerman | TX | Lake Creek (Montgomery) | 2021 | SS | 2024 | 3 | Phillies |
| Ryan Spikes | GA | Parkview | 2021 | SS | 2021 | 3rd | Tampa Bay Rays |
| Bren Spillane | IL | Wheeling | 2015 | 1B | 2018 | 3 | Reds |
| Ben Spitznagel | OH | Colerain | 2013 | OF | 2017 | 27 | Athletics |
| Jared Sprague-Lott | PA | Springside Chestnut Hill | 2020 | SS | 2024 | 9 | Athletics |
| Blair Springfield | IL | Decatur MacArthur | 2009 | SS | 2009 | 7 | Cubs |
| Jordan Sprinkle | CA | Palm Desert | 2019 | SS | 2022 | 4 | White Sox |
| Brandon Sproat | FL | Pace | 2019 | RHP | 2022 | 3 | Mets |
| Fitz Stadler | IL | Glenbrook South | 2015 | RHP | 2018 | 18 | Blue Jays |
| Ryan Stafford | CA | Folsom | 2021 | C | 2024 | 5 | Orioles |
| Deon Stafford Jr. | PA | Lower Dauphin | 2014 | C | 2017 | 5 | Pirates |
| Samuel Stafura | NY | Walter Panas | 2023 | SS | 2023 | 2 | Cincinnati Reds |
| Connor Staine | NJ | West Morris Central | 2019 | RHP | 2022 | 5 | Rockies |
| Carl Stajduhar | CO | Rocky Mountain | 2014 | RHP | 2014 | 27 | Braves |
| Garrett Stallings | VA | Grassfield | 2016 | RHP | 2019 | 5th | Angels |
| Mitch Stalsberg | WI | Viroqua | 2014 | LHP | 2017 | 23 | Tigers |
| Gage Stanifer | IN | Westfield | 2022 | RHP | 2022 | 19 | Blue Jays |
| Hunter Stanley | MS | N/A | 2016 | SS | 2021 | 11 | Indians |
| Max Stanley | CO | Douglas County | 2023 | RHP | 2023 | 20 | Rays |
| Tyler Statler | IL | Hononegah | 2019 | RHP | 2019 | 14 | Cardinals |
| Adam Stauffer | PA | Coatesville Area | 2017 | RHP | 2017 | 19 | Orioles |
| Isaac Stebens | OK | Stillwater | 2020 | RHP | 2023 | 16 | Red Sox |
| Logan Steenstra | MO | Liberty | 2018 | SS | 2019 | 40 | Twins |
| Hunter Steinmetz | MO | Parkview | 2015 | OF | 2018 | 11 | Blue Jays |
| Jacob Steinmetz | NY | Hebrew Academy Five Towns and Rockaways | 2021 | RHP | 2021 | 3 | Arizona Diamondbacks |
| Khal Stephen | IN | Seeger | 2021 | RHP | 2024 | 2 | Blue Jays |
| Seth Stephenson | TX | Jack C Hays | 2019 | OF | 2022 | 7 | Tigers |
| Levi Sterling | CA | Notre Dame | 2024 | RHP | 2024 | CB-A | Pirates |
| Zach Sterry | OH | Lexington | 2013 | OF | 2017 | 8 | Red Sox |
| Sammy Stevens | MI | Brother Rice | 2014 | C | 2014 | 34 | Tigers |
| Will Stevens | MO | Park Hill | 2019 | RHP | 2023 | 15 | Rays |
| Jake Stevenson | MN | Waconia | 2015 | RHP | 2019 | 10 | Reds |
| Tommy Stevenson | MO | Kirkwood | 2019 | C | 2022 | 19 | Athletics |
| Owen Stevenson | CA | Sacred Heart Cathedral | 2020 | RHP | 2023 | 19 | Rays |
| Brock Stewart | IL | Normal West | 2010 | RHP | 2014 | 6 | Dodgers |
| Joe Stewart | MI | Portage Central | 2016 | OF | 2022 | 9 | Angels |
| Devan (DJ) Stewart | MO | Westminster | 2017 | SS | 2017 | 39 | Phillies |